Particle Image Velocimetry Measurements of a Dry Powder Inhaler Flow

Authors

  • Vishal Chaugule Laboratory for Turbulence Research in Aerospace and Combustion (LTRAC), Department of Mechanical and Aerospace Engineering, Monash University
  • Larissa Gomes dos Reis Respiratory Technology, Woolcock Institute of Medical Research, Australia
  • David F. Fletcher School of Chemical and Biomolecular Engineering, The University of Sydney, Australia
  • Paul M. Young Respiratory Technology, Woolcock Institute of Medical Research, Australia; Department of Marketing, Macquarie Business School, Macquarie University, Australia
  • Daniela Traini Respiratory Technology, Woolcock Institute of Medical Research, Australia; Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Australia
  • Julio Soria Laboratory for Turbulence Research in Aerospace & Combustion (LTRAC) Department of Mechanical and Aerospace Engineering, Monash University, Australia

DOI:

https://doi.org/10.18409/ispiv.v1i1.199

Keywords:

dry powder inhaler, swirling flow, aerosol performance, inhaler design

Abstract

Inhalation therapy for respiratory disorders is being increasingly delivered via dry powder inhalers (DPIs), which are breath-actuated devices that deliver pharmaceutical drug particles to the lungs. The motion of inhalation air, produced when a patient inhales through this device, supplies all energy for the entrainment, de-agglomeration, and dispersion of powder drug agglomerates into a fine drug particle aerosol. The aerosol performance is directly related to the fluid-mechanics of a given DPI device. These flow mechanisms are complex as they depend on the device design, inhalation flow rate, and the properties of the dry powder formulation used. Among these, the role of device design is crucial as it significantly affects not only the generation and properties of delivered aerosol, but also the capability of targeted regional drug deposition.

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Published

2021-08-01

Issue

Vol. 1 No. 1 (2021)

Section

Biological Flows

License

Copyright for all articles and abstracts is retained by their respective authors